With everything setup normall in the UI and working, the following commands will enable/disable a WireGuard connection.

Enable WireGuard

The following must be Run as Admin. Replace NAME_OF_CONNECTION with the name of the connection

& "C:\Program Files\WireGuard\wireguard.exe" /installtunnelservice "C:\Program Files\WireGuard\Data\Configurations\NAME_OF_CONNECTION.conf.dpapi"

Disable WireGuard

The following must also be Run as Admin. Replace NAME_OF_CONNECTION with the name of the ocnnection.

& "C:\Program Files\WireGuard\wireguard.exe" /uninstalltunnelservice "NAME_OF_CONNECTION"